CACNA1C

Across TCGA patient cohorts, CACNA1C protein abundance is significantly associated with the RNA expression of many other genes, with 2,418 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CACNA1C-associated genes across cancer lineages are GABRG2, HS3ST2, and NPY. Each is linked with CACNA1C in more than 1 cancer types. Because this analysis shows association rather than direction, both CACNA1C-to-partner and partner-to-CACNA1C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CACNA1C versus GABRG2 in GBM, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1C→partner) and Y-score (partner→CACNA1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GABRG2 →	+1.000	+0.376	<.001	.004	3	2
LSCC	HS3ST2 →	+1.576	+0.727	.004	<.001	3	2
GBM	NPY →	+1.520	+0.417	<.001	.006	3	2
GBM	TPH2 →	+0.153	+0.596	<.001	<.001	3	2
GBM	NYAP2 →	+0.999	+0.616	<.001	<.001	3	2
GBM	GLT1D1 →	+1.333	+0.620	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,418 associations by consensus.

CACNA1C vs GABRG2 — GBM

Explore this scatter interactively →