CACNA1C

Across TCGA pan-cancer cohorts, CACNA1C RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CACNA1C data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CACNA1C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CACNA1C expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRP, OV, and MESO are the cancer types where CACNA1C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.505	0.863	<.001	122	view →
OV	OS	Tertile	II,III,IV	0.592	0.762	<.001	94	view →
MESO	OS	Tertile	II,III,IV	0.280	0.604	<.001	75	view →
UVM	DFS	Quartile	II,III,IV	0.397	0.844	<.001	56	view →
KIRC	DFS	Median	All	0.749	0.517	.002	50	view →
HNSC	DFS	Tertile	IV	0.790	0.576	.002	47	view →
UCS	DFS	Median	III,IV	0.469	0.115	<.001	44	view →
BLCA	OS	Quartile	II,III,IV	0.523	0.695	.005	38	view →
LUAD	OS	Tertile	II,III,IV	0.629	0.343	.005	34	view →
THYM	DFS	Quartile	All	0.965	0.738	.003	26	view →
LAML	DFS	Tertile	All	0.576	0.315	.004	26	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CACNA1C–KIRP (OS)

Open the KIRP breakdown →