CACNA1C

Across TCGA patient cohorts, CACNA1C mutation is significantly associated with the RNA expression of many other genes, with 9,732 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA1C-associated genes across cancer lineages are CKS2, CDKN3, and ITPR1. Each is linked with CACNA1C in more than 6 cancer types. Because this analysis shows association rather than direction, both CACNA1C-to-partner and partner-to-CACNA1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CKS2 grouped by CACNA1C-low versus CACNA1C-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1C→partner) and Y-score (partner→CACNA1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CKS2 →	+0.604	+2.750	.004	.002	3	7
LUAD	CDKN3 →	+0.586	+2.201	.001	<.001	2	7
STAD	ITPR1 →	-0.665	-3.446	.001	.005	3	6
LUAD	CYYR1 →	-0.443	-2.000	<.001	<.001	3	6
SKCM	DTYMK →	+0.365	+1.043	<.001	<.001	3	6
UCEC	SULT1C4 →	-0.547	-1.677	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,732 associations by consensus.

CKS2 by CACNA1C expression — STAD

Explore this box plot interactively →