CACNA1C

Across TCGA patient cohorts, CACNA1C mutation is significantly associated with the total protein of many other genes, with 102 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CACNA1C-associated genes across cancer lineages are c-Kit, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with CACNA1C in more than 4 cancer types. Because this analysis shows association rather than direction, both CACNA1C-to-partner and partner-to-CACNA1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by CACNA1C-low versus CACNA1C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1C→partner) and Y-score (partner→CACNA1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	c-Kit →	-0.598	-1.906	.001	.014	3	5
COAD	Caspase-7-cleavedD198 →	+1.257	+3.104	<.001	<.001	3	5
BRCA	Cyclin-B1 →	+0.683	+2.700	.004	.006	3	4
LUAD	Dvl3 →	+0.110	+2.321	.038	.005	3	4
COAD	MYH11 →	-1.265	-2.459	.002	.017	3	4
COAD	PCNA →	+0.307	+2.008	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

c-Kit by CACNA1C expression — COAD

Explore this box plot interactively →