CACNA1C

Across TCGA cell cohorts, CACNA1C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,024 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CACNA1C-associated GO terms across cancer lineages are Cellular response to UV, Negative regulation of ossification, and Regulation of endosome organization. Each is linked with CACNA1C in more than 7 cancer types. Because this analysis shows association rather than direction, both CACNA1C-to-partner and partner-to-CACNA1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to UV grouped by CACNA1C-low versus CACNA1C-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1C→partner) and Y-score (partner→CACNA1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Cellular response to UV →	+0.043	+0.734	.002	.005	3	8
BONE	Negative regulation of ossification →	+0.071	+1.456	.004	.001	3	6
BONE	Regulation of endosome organization →	+0.178	+1.563	.002	.003	3	6
PANCREAS	Cellular response to unfolded protein →	+0.097	+0.363	<.001	.002	3	6
PANCREAS	Response to topologically incorrect protein →	+0.081	+0.359	.001	.003	3	6
CNS	Protein localization to vacuole →	+0.054	+1.198	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,024 associations by consensus.

Cellular response to UV by CACNA1C expression — SKIN

Explore this box plot interactively →