CACNA1C

Across TCGA cell cohorts, CACNA1C mutation is significantly associated with the RNA expression of many other genes, with 993 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA1C-associated genes across cancer lineages are FBXW10, KLHL40, and TAF1L. Each is linked with CACNA1C in more than 3 cancer types. Because this analysis shows association rather than direction, both CACNA1C-to-partner and partner-to-CACNA1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by CACNA1C-low versus CACNA1C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1C→partner) and Y-score (partner→CACNA1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.156	+3.562	.002	<.001	3	4
BLOOD_Leukemia	KLHL40 →	+0.004	+2.979	<.001	.007	3	3
CNS	TAF1L →	+0.088	+2.584	.002	.008	2	4
LARGE_INTESTINE	TAF4B →	+0.695	+3.043	<.001	<.001	3	3
LARGE_INTESTINE	C22orf46 →	+0.829	+3.169	.001	.006	3	3
BLOOD_Lymphoma	IRGC →	+0.029	+3.502	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 993 associations by consensus.

FBXW10 by CACNA1C expression — LARGE_INTESTINE

Explore this box plot interactively →