CACNA1C-IT1

Across TCGA pan-cancer cohorts, CACNA1C-IT1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated CACNA1C-IT1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher CACNA1C-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CACNA1C-IT1 expression acts as an unfavorable survival marker, although some lineages such as THCA and CHOL show a favorable association.

UCS, BLCA, and PAAD are the cancer types where CACNA1C-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	All	0.100	0.531	.002	72	view →
BLCA	OS	Tertile	IV	0.051	0.600	<.001	48	view →
PAAD	DFS	Tertile	All	0.076	0.468	<.001	36	view →
ESCA	OS	Tertile	IV	0.095	0.512	.008	36	view →
KICH	DFS	Tertile	All	0.162	0.862	.014	30	view →
PCPG	OS	Tertile	All	0.330	0.971	.002	27	view →
THYM	DFS	Tertile	All	0.092	0.872	<.001	18	view →
LUSC	DFS	Tertile	II,III,IV	0.258	0.719	.008	18	view →
READ	DFS	Tertile	II,III,IV	0.112	0.800	.002	18	view →
SKCM	DFS	Tertile	III,IV	0.233	0.549	.044	9	view →
COAD	OS	Tertile	III,IV	0.140	0.696	.027	9	view →
ACC	DFS	Tertile	II,III,IV	0.226	0.725	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

CACNA1C-IT1–UCS (DFS)

Open the UCS breakdown →