CACNA1C-IT1

Across TCGA pan-cancer cohorts, CACNA1C-IT1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CACNA1C-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CACNA1C-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types CACNA1C-IT1 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KIRP, and KICH are the cancer types where CACNA1C-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CACNA1C-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−0.142	.032	4	view →
KIRP	All	III,IV	+0.048	.016	3	view →
KICH	All	All	−0.031	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CACNA1C-IT1–BLCA

Open the BLCA breakdown →