CACNA1C-AS2

Across TCGA pan-cancer cohorts, CACNA1C-AS2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CACNA1C-AS2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CACNA1C-AS2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CACNA1C-AS2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LIHC show a favorable association.

HNSC, LIHC, and LUAD are the cancer types where CACNA1C-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.729	0.596	.001	41	view →
LIHC	DFS	Median	All	0.515	0.368	.001	38	view →
LUAD	DFS	Median	All	0.847	0.735	<.001	36	view →
CESC	OS	Tertile	All	0.847	0.691	.005	26	view →
BRCA	DFS	Quartile	All	0.600	0.503	.016	20	view →
READ	DFS	Quartile	All	0.589	0.841	.009	20	view →
THYM	OS	Median	All	0.965	0.736	.004	19	view →
KIRC	DFS	Median	II,III,IV	0.435	0.606	.004	18	view →
OV	OS	Tertile	III,IV	0.773	0.874	.008	16	view →
KIRP	OS	Median	All	0.776	0.600	.004	16	view →
SKCM	OS	Median	IV	0.867	0.244	.006	15	view →
ACC	DFS	Median	II,III,IV	0.411	0.714	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CACNA1C-AS2–HNSC (DFS)

Open the HNSC breakdown →