CACNA1C-AS2

Across TCGA pan-cancer cohorts, CACNA1C-AS2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CACNA1C-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CACNA1C-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CACNA1C-AS2 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

KIRC, LUAD, and BRCA are the cancer types where CACNA1C-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CACNA1C-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.319	<.001	9	view →
LUAD	All	III,IV	−0.604	<.001	7	view →
BRCA	All	III,IV	−0.342	.006	6	view →
KICH	All	All	−0.198	.010	5	view →
LUSC	All	III,IV	−0.818	.003	3	view →
BLCA	All	IV	−0.455	.004	3	view →
UCEC	All	All	+0.509	.018	2	view →
COAD	Female	II,III,IV	+0.344	.030	2	view →
LIHC	Male	II,III,IV	−0.251	.025	2	view →
ESCA	All	All	−0.401	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CACNA1C-AS2–KIRC

Open the KIRC breakdown →