CACNA1C-AS1

Across TCGA pan-cancer cohorts, CACNA1C-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CACNA1C-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CACNA1C-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CACNA1C-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

COAD, HNSC, and UCS are the cancer types where CACNA1C-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.479	0.747	<.001	65	view →
HNSC	DFS	Tertile	IV	0.794	0.584	.004	60	view →
UCS	OS	Tertile	II,III,IV	0.732	0.289	.005	54	view →
MESO	OS	Quartile	III,IV	0.279	0.572	.009	27	view →
UCEC	DFS	Quartile	All	0.540	0.789	.010	24	view →
LGG	DFS	Median	All	0.287	0.483	<.001	22	view →
THYM	OS	Median	All	1.000	0.708	<.001	21	view →
OV	OS	Tertile	III,IV	0.760	0.889	<.001	20	view →
SKCM	OS	Quartile	IV	0.817	0.188	.001	19	view →
KIRC	DFS	Median	II,III,IV	0.449	0.594	.009	19	view →
CHOL	DFS	Quartile	All	0.789	0.189	.010	15	view →
PAAD	DFS	Tertile	II,III,IV	0.438	0.276	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CACNA1C-AS1–COAD (OS)

Open the COAD breakdown →