CACNA1C-AS1

Across TCGA pan-cancer cohorts, CACNA1C-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CACNA1C-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CACNA1C-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CACNA1C-AS1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where CACNA1C-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CACNA1C-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.080	<.001	5	view →
KICH	Male	All	−0.095	.003	4	view →
HNSC	All	All	+0.060	.022	4	view →
COAD	Female	IV	+0.464	.012	3	view →
LUSC	Male	III,IV	−0.297	.016	3	view →
THCA	Female	II,III,IV	−0.123	.018	3	view →
BLCA	All	IV	−0.300	.009	2	view →
LUAD	Male	III,IV	−0.175	.005	2	view →
PRAD	All	All	+0.084	.016	2	view →
STAD	All	IV	−0.263	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CACNA1C-AS1–KIRC

Open the KIRC breakdown →