CACNA1B

Across TCGA patient cohorts, CACNA1B mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA1B-associated genes across cancer lineages are IGFBP2, Caspase-7-cleavedD198, and Di-Ras3. Each is linked with CACNA1B in more than 4 cancer types. Because this analysis shows association rather than direction, both CACNA1B-to-partner and partner-to-CACNA1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by CACNA1B-low versus CACNA1B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1B→partner) and Y-score (partner→CACNA1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	IGFBP2 →	-0.871	-3.000	.008	.035	3	5
COAD	Caspase-7-cleavedD198 →	+0.916	+2.123	<.001	<.001	3	5
UCEC	Di-Ras3 →	-0.141	-2.986	<.001	<.001	3	4
UCEC	Annexin-1 →	+0.469	+1.836	<.001	<.001	3	4
STAD	Smad1 →	+0.123	+2.000	.009	.028	3	3
STAD	ASNS →	+0.369	+1.906	.012	.013	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

IGFBP2 by CACNA1B expression — LUSC

Explore this box plot interactively →