CACNA1B

Across TCGA pan-cancer cohorts, CACNA1B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CACNA1B data layer compared with 13 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CACNA1B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CACNA1B expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

UCEC, HNSC, and PAAD are the cancer types where CACNA1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.515	0.727	<.001	104	view →
HNSC	OS	Median	IV	0.672	0.526	.003	80	view →
PAAD	DFS	Median	All	0.440	0.264	<.001	56	view →
BRCA	OS	Tertile	II,III,IV	0.470	0.710	.004	46	view →
KIRC	DFS	Quartile	All	0.466	0.725	.007	44	view →
KIRP	OS	Median	All	0.448	0.811	<.001	39	view →
ACC	DFS	Median	All	0.540	0.903	.003	35	view →
LGG	OS	Median	All	0.933	0.856	<.001	31	view →
LIHC	OS	Tertile	III,IV	0.199	0.521	.003	19	view →
THCA	OS	Tertile	All	0.951	0.988	.015	18	view →
SKCM	OS	Median	All	0.285	0.390	.005	15	view →
UVM	DFS	Median	All	0.343	0.575	.011	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CACNA1B–UCEC (DFS)

Open the UCEC breakdown →