CACNA1B

Across TCGA cell cohorts, CACNA1B mutation is significantly associated with the RNA expression of many other genes, with 1,861 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA1B-associated genes across cancer lineages are PIH1D1, TTC33, and KLHL11. Each is linked with CACNA1B in more than 3 cancer types. Because this analysis shows association rather than direction, both CACNA1B-to-partner and partner-to-CACNA1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIH1D1 grouped by CACNA1B-low versus CACNA1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1B→partner) and Y-score (partner→CACNA1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PIH1D1 →	+0.434	+2.321	.001	<.001	3	4
LARGE_INTESTINE	TTC33 →	+0.683	+1.891	<.001	<.001	3	4
LARGE_INTESTINE	KLHL11 →	+0.719	+1.545	<.001	.004	3	4
CNS	C3orf62 →	+0.437	+2.584	.004	.006	3	3
LARGE_INTESTINE	RNF8 →	+0.550	+1.891	<.001	<.001	3	3
LARGE_INTESTINE	WRAP73 →	+0.547	+1.891	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,861 associations by consensus.

PIH1D1 by CACNA1B expression — LARGE_INTESTINE

Explore this box plot interactively →