CABS1

Across TCGA patient cohorts, CABS1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CABS1-associated genes across cancer lineages are 4E-BP1, Myosin-IIa_pS1943, and Notch1. Each is linked with CABS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CABS1-to-partner and partner-to-CABS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CABS1-low versus CABS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CABS1→partner) and Y-score (partner→CABS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.385	+3.169	.001	.018	3	3
UCEC	Myosin-IIa_pS1943 →	+0.196	+3.000	.030	.036	3	2
UCEC	Notch1 →	+0.122	+2.820	.047	.035	3	2
UCEC	Tuberin →	+0.395	+2.469	<.001	.010	3	2
LUAD	4E-BP1_pS65 →	+0.152	+3.321	.028	.010	3	1
UCEC	EGFR_pY1068 →	-0.267	-2.321	.014	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

4E-BP1 by CABS1 expression — UCEC

Explore this box plot interactively →