CAB39

Across TCGA pan-cancer cohorts, CAB39 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CAB39 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CAB39 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CAB39 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where CAB39 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.903	0.305	.006	30	view →
PDAC	DFS	Quartile	All	0.687	0.909	.006	28	view →
CCRCC	DFS	Median	II,III,IV	0.979	0.163	.003	23	view →
LSCC	OS	Quartile	II,III,IV	0.476	0.933	.004	13	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CAB39–HNSC (DFS)

Open the HNSC breakdown →