CAB39

Across TCGA pan-cancer cohorts, CAB39 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CAB39’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CAB39 RNA is repressed in tumor relative to normal tissue. In most cancer types CAB39 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and COAD are the cancer types where CAB39 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAB39 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.086	<.001	10	view →
KIRC	Male	III,IV	−0.666	<.001	10	view →
COAD	Female	All	−0.961	<.001	9	view →
LIHC	All	III,IV	+0.693	<.001	9	view →
HNSC	All	II,III,IV	+0.463	<.001	9	view →
CHOL	All	All	+1.490	<.001	5	view →
PAAD	Male	All	+0.525	.020	4	view →
BLCA	Male	All	−0.470	.033	4	view →
LUSC	Female	All	−0.452	.005	4	view →
READ	All	All	−0.678	<.001	3	view →
THCA	All	IV	−0.835	.018	2	view →
UCEC	All	All	−0.781	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CAB39–KICH

Open the KICH breakdown →