CAB39

Across TCGA patient cohorts, CAB39 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAB39-associated genes across cancer lineages are A-Raf_pS299, JNK_pT183_Y185, and JNK2. Each is linked with CAB39 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAB39-to-partner and partner-to-CAB39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CAB39-low versus CAB39-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAB39→partner) and Y-score (partner→CAB39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.157	-2.321	.001	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.201	-2.308	.003	.006	3	1
UCEC	JNK2 →	+0.180	+1.807	.028	.027	3	1
UCEC	Ku80 →	+0.298	+2.335	.002	.003	3	1
UCEC	p21 →	+0.165	+3.169	.037	.019	3	1
UCEC	p70-S6K_pT389 →	-0.199	-2.999	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

A-Raf_pS299 by CAB39 expression — UCEC

Explore this box plot interactively →