CA9

Across TCGA pan-cancer cohorts, CA9 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CA9’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CA9 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CA9 is over-expressed in tumor.

CCRCC, HNSC, and PDAC are the cancer types where CA9 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CA9 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	IV	+2.016	<.001	12	view →
HNSC	All	IV	+1.113	<.001	8	view →
PDAC	All	II,III,IV	+0.707	<.001	8	view →
LSCC	All	All	+0.703	<.001	7	view →
COAD	All	All	+0.693	.001	6	view →
LUAD	Male	All	+0.630	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

CA9–CCRCC

Open the CCRCC breakdown →