CA8

Across TCGA pan-cancer cohorts, CA8 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CA8 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CA8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CA8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, GBM, and HNSC are the cancer types where CA8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.691	0.309	.004	40	view →
GBM	OS	Median	All	0.275	0.472	.003	14	view →
HNSC	DFS	Median	IV	0.815	0.505	.001	12	view →
UCEC	DFS	Quartile	All	0.937	0.700	.007	10	view →
LUAD	DFS	Tertile	III,IV	0.546	1.000	.016	8	view →
CCRCC	OS	Median	All	1.000	0.680	.025	4	view →
LSCC	DFS	Median	II,III,IV	0.902	0.969	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CA8–PDAC (OS)

Open the PDAC breakdown →