CA8

Across TCGA pan-cancer cohorts, CA8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CA8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CA8 RNA is repressed in tumor relative to normal tissue. In most cancer types CA8 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where CA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−2.723	<.001	12	view →
KICH	Male	II,III,IV	−2.842	<.001	9	view →
KIRP	Male	All	−2.303	<.001	9	view →
UCEC	All	All	+1.603	<.001	6	view →
LUSC	Female	All	−1.185	<.001	6	view →
BLCA	Male	IV	−1.295	<.001	5	view →
HNSC	Male	All	−0.734	.003	4	view →
BRCA	Female	II,III,IV	−0.630	.002	4	view →
LIHC	All	All	+0.210	<.001	4	view →
LUAD	Female	All	−0.488	.013	2	view →
CHOL	All	All	+0.926	.049	1	view →
STAD	Male	All	+0.848	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CA8–KIRC

Open the KIRC breakdown →