CA3-AS1

Across TCGA pan-cancer cohorts, CA3-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CA3-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher CA3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CA3-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LIHC show a favorable association.

UVM, LGG, and OV are the cancer types where CA3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.321	0.728	<.001	95	view →
LGG	DFS	Median	All	0.650	0.810	<.001	50	view →
OV	DFS	Tertile	All	0.138	0.236	.006	48	view →
UCS	OS	Median	IV	0.732	0.224	.018	36	view →
LIHC	OS	Tertile	III,IV	0.646	0.200	.002	32	view →
LUSC	OS	Tertile	II,III,IV	0.703	0.535	.018	19	view →
CESC	DFS	Median	IV	0.093	0.435	.027	18	view →
LUAD	DFS	Median	III,IV	0.534	0.734	.005	17	view →
THCA	OS	Median	IV	0.551	0.924	.006	15	view →
ACC	DFS	Median	IV	0.089	0.472	.012	10	view →
SKCM	OS	Quartile	IV	1.000	0.239	.018	9	view →
STAD	OS	Median	IV	0.642	0.203	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CA3-AS1–UVM (DFS)

Open the UVM breakdown →