CA3-AS1

Across TCGA pan-cancer cohorts, CA3-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CA3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CA3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types CA3-AS1 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and THCA are the cancer types where CA3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CA3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	−2.340	<.001	12	view →
LUAD	Female	III,IV	−1.153	<.001	11	view →
THCA	All	III,IV	−0.585	<.001	10	view →
READ	All	II,III,IV	−2.092	<.001	7	view →
KICH	Female	All	+1.606	<.001	6	view →
LUSC	Female	II,III,IV	−0.874	<.001	6	view →
BRCA	All	All	−0.514	<.001	6	view →
STAD	All	All	+0.379	.010	4	view →
HNSC	Female	All	+0.505	.017	2	view →
PRAD	All	All	−0.453	<.001	2	view →
LIHC	All	All	+0.279	.027	2	view →
CHOL	All	All	+0.758	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CA3-AS1–COAD

Open the COAD breakdown →