CA12

Across TCGA patient cohorts, CA12 mutation is significantly associated with the RNA expression of many other genes, with 1,923 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA12-associated genes across cancer lineages are MIR3649, RN7SKP60, and GPR32. Each is linked with CA12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA12-to-partner and partner-to-CA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3649 grouped by CA12-low versus CA12-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA12→partner) and Y-score (partner→CA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR3649 →	+0.683	+4.086	.005	.005	3	2
SKCM	RN7SKP60 →	+0.099	+4.147	<.001	.008	3	2
UCEC	GPR32 →	+0.288	+1.936	<.001	.009	3	2
SKCM	TRIM42 →	+0.032	+3.099	<.001	.007	3	2
UCEC	LINC02210-CRHR1 →	+0.060	+2.273	.004	.006	3	2
UCEC	MIR4445 →	+0.169	+4.390	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,923 associations by consensus.

MIR3649 by CA12 expression — LUSC

Explore this box plot interactively →