CA12

Across TCGA pan-cancer cohorts, CA12 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CA12 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CA12 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CA12 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCEC show a favorable association.

UVM, UCS, and PAAD are the cancer types where CA12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.373	0.797	<.001	156	view →
UCS	DFS	Median	III,IV	0.221	0.625	<.001	74	view →
PAAD	OS	Median	All	0.252	0.523	<.001	65	view →
LUAD	DFS	Quartile	All	0.624	0.851	.001	64	view →
BRCA	DFS	Median	III,IV	0.933	0.816	<.001	50	view →
HNSC	DFS	Quartile	III,IV	0.197	0.464	.001	46	view →
UCEC	DFS	Tertile	All	0.806	0.489	.004	30	view →
LGG	OS	Quartile	All	0.725	0.882	<.001	28	view →
KIRP	DFS	Median	All	0.857	0.978	<.001	23	view →
DLBC	OS	Tertile	III,IV	1.000	0.272	.012	22	view →
CESC	OS	Quartile	All	0.490	0.780	.010	22	view →
STAD	DFS	Tertile	IV	0.746	0.149	.016	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CA12–UVM (DFS)

Open the UVM breakdown →