CA12

Across TCGA patient cohorts, CA12 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA12-associated genes across cancer lineages are JNK2, MEK1, and Notch1. Each is linked with CA12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA12-to-partner and partner-to-CA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CA12-low versus CA12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA12→partner) and Y-score (partner→CA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.301	+3.026	.001	.018	3	1
UCEC	MEK1 →	+0.593	+3.459	<.001	.005	3	1
UCEC	Notch1 →	+0.163	+3.183	.013	.009	3	1
UCEC	PCNA →	+0.309	+2.321	.002	.034	3	1
UCEC	Bap1-c-4 →	+0.206	+3.019	.043	.019	3	1
UCEC	Caspase-8 →	-0.235	-3.295	.045	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK2 by CA12 expression — UCEC

Explore this box plot interactively →