CA11

Across TCGA patient cohorts, CA11 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA11-associated genes across cancer lineages are eIF4E, FASN, and JNK_pT183_Y185. Each is linked with CA11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA11-to-partner and partner-to-CA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CA11-low versus CA11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA11→partner) and Y-score (partner→CA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.202	+2.000	.034	.032	3	2
UCEC	FASN →	+0.406	+2.000	.022	.032	3	2
UCEC	JNK_pT183_Y185 →	-0.185	-1.986	.015	.032	3	2
UCEC	PKC-b-II_pS660 →	-0.291	-2.459	.019	.019	3	2
UCEC	Rictor_pT1135 →	-0.106	-2.999	.021	.035	3	2
UCEC	Src_pY527 →	-0.420	-2.999	.030	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

eIF4E by CA11 expression — UCEC

Explore this box plot interactively →