CA11

Across TCGA cell cohorts, CA11 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CA11-associated genes across cancer lineages are OR1L3, RTL4, and KRTAP4-8. Each is linked with CA11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA11-to-partner and partner-to-CA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by CA11-low versus CA11-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA11→partner) and Y-score (partner→CA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	1
SKIN	RTL4 →	+0.004	+4.415	<.001	.007	3	1
SKIN	KRTAP4-8 →	+1.552	+4.467	<.001	.004	3	1
SKIN	KRTAP4-11 →	+0.014	+4.415	<.001	.007	3	1
SKIN	SKOR2 →	+0.326	+4.095	<.001	.009	3	1
SKIN	TFAP2D →	+0.115	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR1L3 by CA11 expression — SKIN

Explore this box plot interactively →