C9orf85

Across TCGA patient cohorts, C9orf85 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible C9orf85-associated genes across cancer lineages are RNA5SP519, BAK1P2, and UGT1A9. Each is linked with C9orf85 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf85-to-partner and partner-to-C9orf85 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP519 grouped by C9orf85-low versus C9orf85-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf85→partner) and Y-score (partner→C9orf85) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP519 →	+0.409	+5.098	<.001	<.001	3	2
SKCM	BAK1P2 →	+0.146	+4.243	<.001	.003	3	1
SKCM	UGT1A9 →	+0.091	+3.913	<.001	.006	3	1
SKCM	SSX2 →	+0.218	+4.333	.003	.003	3	1
CESC	NFU1P2 →	+0.121	+7.164	<.001	<.001	3	1
CESC	MTND2P6 →	+0.055	+6.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

RNA5SP519 by C9orf85 expression — SKCM

Explore this box plot interactively →