C9orf85

Across TCGA pan-cancer cohorts, C9orf85 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated C9orf85 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher C9orf85 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated C9orf85 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, ACC, and KIRP are the cancer types where C9orf85 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.735	0.535	<.001	94	view →
ACC	DFS	Tertile	All	0.344	0.806	<.001	70	view →
KIRP	DFS	Tertile	All	0.867	0.981	.002	39	view →
LGG	OS	Median	All	0.948	0.828	<.001	33	view →
THYM	DFS	Median	All	0.952	0.789	.001	28	view →
LIHC	DFS	Quartile	All	0.317	0.537	<.001	28	view →
STAD	DFS	Tertile	IV	0.197	0.555	.010	19	view →
TGCT	DFS	Median	All	0.745	0.919	.002	16	view →
SCLC	OS	Quartile	II,III,IV	0.654	0.190	.010	16	view →
MESO	OS	Tertile	III,IV	0.445	0.672	.008	12	view →
THCA	DFS	Tertile	All	0.992	0.921	.004	12	view →
UVM	DFS	Median	III,IV	0.302	0.889	.007	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

C9orf85–KIRC (DFS)

Open the KIRC breakdown →