C9orf72

Across TCGA patient cohorts, C9orf72 protein abundance is significantly associated with the RNA expression of many other genes, with 4,417 significant associations in total. GBM shows the largest number of these associations.

The most reproducible C9orf72-associated genes across cancer lineages are CAAP1, ZNF181, and EQTN. Each is linked with C9orf72 in more than 2 cancer types. Because this analysis shows association rather than direction, both C9orf72-to-partner and partner-to-C9orf72 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C9orf72 versus CAAP1 in LSCC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf72→partner) and Y-score (partner→C9orf72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CAAP1 →	+0.623	+0.354	<.001	<.001	3	3
GBM	ZNF181 →	-0.328	-0.226	.006	.002	3	3
GBM	EQTN →	+0.379	+0.261	.009	.001	3	3
GBM	PLAA →	+0.643	+0.234	.001	.002	3	3
HNSC	IFNK →	+0.811	+0.463	.006	<.001	3	3
UCEC	PQBP1 →	-0.984	-0.291	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,417 associations by consensus.

C9orf72 vs CAAP1 — LSCC

Explore this scatter interactively →