C9orf64

Across TCGA patient cohorts, C9orf64 mutation is significantly associated with the RNA expression of many other genes, with 617 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf64-associated genes across cancer lineages are RNU6-958P, RAD51, and RNA5SP146. Each is linked with C9orf64 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf64-to-partner and partner-to-C9orf64 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-958P grouped by C9orf64-low versus C9orf64-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf64→partner) and Y-score (partner→C9orf64) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-958P →	+0.687	+6.444	<.001	.001	3	2
UCEC	RAD51 →	+0.770	+2.595	.002	.006	3	2
BLCA	RNA5SP146 →	+0.384	+4.799	<.001	.003	3	2
UCEC	CRYBB2P1 →	+0.513	+2.606	.006	.006	3	2
UCEC	VPS18 →	+0.548	+3.475	.004	.002	3	2
UCEC	MAP1LC3B →	+0.607	+3.711	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 617 associations by consensus.

RNU6-958P by C9orf64 expression — LUAD

Explore this box plot interactively →