Across TCGA patient cohorts, C9orf57 mutation is significantly associated with the RNA expression of many other genes, with 371 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf57-associated genes across cancer lineages are SNORD114-18, ABHD17AP9, and SLC25A4. Each is linked with C9orf57 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf57-to-partner and partner-to-C9orf57 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf57→partner) and Y-score (partner→C9orf57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD114-18 →	+0.337	+2.840	.004	.004	3	2
BRCA	ABHD17AP9 →	+0.104	+8.055	<.001	.007	3	1
UCEC	SLC25A4 →	+0.529	+2.711	.008	.003	3	1
UCEC	DGKE →	+0.627	+3.385	<.001	.004	3	1
UCEC	C16orf87 →	+0.517	+2.743	.005	.003	3	1
UCEC	RNF166 →	+0.580	+3.828	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 371 associations by consensus.

Exploration

C9orf57 survival (RNA) · tumor vs normal (RNA) · all C9orf57 data types