Across TCGA pan-cancer cohorts, C9orf57 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated C9orf57 data layer compared with 5 for mutation status.
The strongest signal is observed in thyroid carcinoma (THCA), where higher C9orf57 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C9orf57 expression acts as an unfavorable survival marker, although some lineages such as LAML and LUAD show a favorable association.
THCA, ACC, and UVM are the cancer types where C9orf57 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.