C9orf50

Across TCGA patient cohorts, C9orf50 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,159 significant associations in total. STAD shows the largest number of these associations.

The most reproducible C9orf50-associated GO terms across cancer lineages are Intracellular sphingolipid homeostasis, Protein hydroxylation, and Regulation of protein folding. Each is linked with C9orf50 in more than 21 cancer types. Because this analysis shows association rather than direction, both C9orf50-to-partner and partner-to-C9orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular sphingolipid homeostasis grouped by C9orf50-low versus C9orf50-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf50→partner) and Y-score (partner→C9orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Intracellular sphingolipid homeostasis →	+0.061	+0.552	<.001	<.001	3	22
CHOL	Protein hydroxylation →	+0.062	+0.568	.001	<.001	3	22
STAD	Regulation of protein folding →	+0.047	+0.296	<.001	<.001	3	21
DLBC	Obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' →	+0.059	+0.300	.003	<.001	2	21
UVM	Regulation of sphingolipid biosynthetic process →	+0.096	+0.538	<.001	<.001	3	19
STAD	Macromolecule deacylation →	+0.055	+0.400	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,159 associations by consensus.

Intracellular sphingolipid homeostasis by C9orf50 expression — UCS

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