C9orf50

Across TCGA patient cohorts, C9orf50 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf50-associated genes across cancer lineages are Di-Ras3, p62 Lck ligand, and PEA-15. Each is linked with C9orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf50-to-partner and partner-to-C9orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by C9orf50-low versus C9orf50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf50→partner) and Y-score (partner→C9orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.160	-2.459	.025	.020	3	1
UCEC	p62 Lck ligand →	+0.353	+2.459	.024	.020	2	1
UCEC	PEA-15 →	+0.187	+2.459	.040	.020	1	1
UCEC	Rab11 →	-0.179	-3.584	.010	.002	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Di-Ras3 by C9orf50 expression — UCEC

Explore this box plot interactively →