C9orf50

Across TCGA cell cohorts, C9orf50 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,860 significant associations in total. CNS shows the largest number of these associations.

The most reproducible C9orf50-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Regulation of myoblast fusion. Each is linked with C9orf50 in more than 9 cancer types. Because this analysis shows association rather than direction, both C9orf50-to-partner and partner-to-C9orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by C9orf50-low versus C9orf50-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf50→partner) and Y-score (partner→C9orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.098	+0.064	<.001	.008	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.101	+0.052	<.001	.009	3	9
CNS	Regulation of myoblast fusion →	+0.051	+0.236	.005	.008	3	9
UPPER_AERODIGESTIVE_TRACT	COPII-coated vesicle budding →	+0.093	+0.069	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.083	+0.065	<.001	.001	3	7
LUNG_NSCLC_LUSC	Cellular respiration →	+0.093	+0.061	<.001	.003	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,860 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by C9orf50 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →