C9orf50

Across TCGA cell cohorts, C9orf50 protein abundance is significantly associated with the go_rna of many other GO terms, with 376 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C9orf50-associated GO terms across cancer lineages are Leptin-mediated signaling pathway, AMP salvage, and Granzyme-mediated programmed cell death signaling pathway. Each is linked with C9orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf50-to-partner and partner-to-C9orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Leptin-mediated signaling pathway grouped by C9orf50-low versus C9orf50-high in BLOOD_Lymphoma.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf50→partner) and Y-score (partner→C9orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Leptin-mediated signaling pathway →	+0.126	+1.358	.002	.003	3	2
BLOOD_Lymphoma	AMP salvage →	-0.155	-1.372	.002	.002	3	2
BLOOD_Leukemia	Granzyme-mediated programmed cell death signaling pathway →	+0.214	+1.711	<.001	.002	3	2
BLOOD_Leukemia	Startle response →	-0.221	-2.220	.002	.004	3	2
BLOOD_Leukemia	Negative regulation of glial cell apoptotic process →	-0.118	-1.671	.007	.003	3	2
BLOOD_Leukemia	GDP-L-fucose metabolic process →	+0.127	+1.742	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 376 associations by consensus.

Leptin-mediated signaling pathway by C9orf50 expression — BLOOD_Lymphoma

Explore this box plot interactively →