C9orf43

Across TCGA patient cohorts, C9orf43 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf43-associated genes across cancer lineages are eEF2, MEK1, and mTOR_pS2448. Each is linked with C9orf43 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf43-to-partner and partner-to-C9orf43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by C9orf43-low versus C9orf43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf43→partner) and Y-score (partner→C9orf43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.332	+3.000	.028	.036	3	2
UCEC	MEK1 →	+0.373	+2.906	.016	.001	3	2
UCEC	mTOR_pS2448 →	-0.145	-2.986	.021	.035	3	2
UCEC	ATM →	-0.627	-4.000	.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.645	+3.169	.006	.018	3	2
UCEC	Cyclin-E2 →	+0.156	+1.884	.029	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eEF2 by C9orf43 expression — UCEC

Explore this box plot interactively →