C9orf43

Across TCGA pan-cancer cohorts, C9orf43 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated C9orf43 data layer compared with 6 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher C9orf43 RNA is associated with better overall survival. In most high-consensus cancer types, elevated C9orf43 expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUSC show a favorable association.

SCLC, ACC, and LIHC are the cancer types where C9orf43 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Quartile	All	0.753	0.320	<.001	94	view →
ACC	DFS	Quartile	All	0.220	0.749	<.001	51	view →
LIHC	DFS	Tertile	III,IV	0.184	0.467	.001	42	view →
LUSC	OS	Tertile	All	0.826	0.710	.004	20	view →
LAML	DFS	Tertile	All	0.715	0.349	.003	18	view →
READ	OS	Tertile	II,III,IV	1.000	0.349	.008	12	view →
PAAD	OS	Quartile	All	0.591	0.380	.027	8	view →
KIRP	DFS	Median	All	0.935	0.586	.008	6	view →
KIRC	DFS	Tertile	All	0.704	0.518	.014	6	view →
UCS	OS	Median	IV	0.248	0.673	.033	6	view →
PCPG	OS	Median	All	0.942	1.000	.032	5	view →
OV	DFS	Quartile	III,IV	0.407	0.313	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

C9orf43–SCLC (OS)

Open the SCLC breakdown →