C9orf43

Across TCGA cell cohorts, C9orf43 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible C9orf43-associated genes across cancer lineages are MYH1, C3orf85, and GHRH. Each is linked with C9orf43 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf43-to-partner and partner-to-C9orf43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH1 grouped by C9orf43-low versus C9orf43-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf43→partner) and Y-score (partner→C9orf43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MYH1 →	+0.022	+5.000	<.001	.006	3	1
PANCREAS	C3orf85 →	+0.132	+5.000	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	GHRH →	+0.051	+4.736	.009	.009	3	1
UPPER_AERODIGESTIVE_TRACT	HSFY1 →	+0.026	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	ANKRD66 →	+0.026	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	RBMY1E →	+0.030	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MYH1 by C9orf43 expression — PANCREAS

Explore this box plot interactively →