C9orf24

Across TCGA cell cohorts, C9orf24 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C9orf24-associated genes across cancer lineages are GJD2 and OR10W1. Each is linked with C9orf24 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf24-to-partner and partner-to-C9orf24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD2 grouped by C9orf24-low versus C9orf24-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf24→partner) and Y-score (partner→C9orf24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJD2 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

GJD2 by C9orf24 expression — LARGE_INTESTINE

Explore this box plot interactively →