C9orf16

Across TCGA pan-cancer cohorts, C9orf16 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C9orf16 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher C9orf16 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated C9orf16 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where C9orf16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.653	.020	16	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	15	view →
HNSC	DFS	Median	All	1.000	0.417	.033	8	view →
GBM	DFS	Median	All	0.437	0.299	.041	3	view →
LSCC	DFS	Quartile	II,III,IV	0.799	1.000	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C9orf16–UCEC (OS)

Open the UCEC breakdown →