Across TCGA pan-cancer cohorts, C9orf135-DT RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of C9orf135-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C9orf135-DT RNA is repressed in tumor relative to normal tissue. In most cancer types C9orf135-DT is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where C9orf135-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C9orf135-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.012	.019	4	view →
KIRP	All	All	−0.031	.001	3	view →
KICH	All	IV	−0.042	.042	1	view →
THCA	Female	II,III,IV	−0.012	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: C9orf135-DT RNA expression & survival · all C9orf135-DT data types