C9orf116

Across TCGA patient cohorts, C9orf116 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf116-associated genes across cancer lineages are OFD1P11Y, RNU6-391P, and MIR525. Each is linked with C9orf116 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf116-to-partner and partner-to-C9orf116 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OFD1P11Y grouped by C9orf116-low versus C9orf116-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf116→partner) and Y-score (partner→C9orf116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OFD1P11Y →	+0.039	+7.816	<.001	.008	3	1
BRCA	RNU6-391P →	+0.301	+7.731	<.001	.009	3	1
BRCA	MIR525 →	+0.591	+7.731	<.001	.009	3	1
UCEC	MIR8070 →	+1.141	+3.132	<.001	.007	3	1
UCEC	PRAMEF13 →	+0.048	+4.132	<.001	.009	3	1
UCEC	MIR3661 →	+0.953	+3.699	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OFD1P11Y by C9orf116 expression — SKCM

Explore this box plot interactively →