C9orf106

Across TCGA patient cohorts, C9orf106 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf106-associated genes across cancer lineages are SNRPGP16, MIR6737, and RPL23AP23. Each is linked with C9orf106 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf106-to-partner and partner-to-C9orf106 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP16 grouped by C9orf106-low versus C9orf106-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf106→partner) and Y-score (partner→C9orf106) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNRPGP16 →	+0.249	+7.930	<.001	.008	3	1
SKCM	MIR6737 →	+0.401	+4.282	<.001	.009	3	1
SKCM	RPL23AP23 →	+0.129	+4.427	<.001	.002	3	1
UCEC	MIR378E →	+0.736	+4.868	<.001	.004	3	1
SKCM	PSMC1P8 →	+0.055	+4.526	<.001	.001	3	1
UCEC	MEMO1P5 →	+0.161	+4.442	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

SNRPGP16 by C9orf106 expression — LUAD

Explore this box plot interactively →