C9

Across TCGA pan-cancer cohorts, C9 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated C9 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher C9 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C9 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, CCRCC, and UCEC are the cancer types where C9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.836	1.000	.018	54	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	29	view →
UCEC	DFS	Quartile	III,IV	0.262	1.000	.008	26	view →
LSCC	DFS	Median	II,III,IV	0.830	1.000	.003	17	view →
PDAC	OS	Median	II,III,IV	0.682	0.970	.006	13	view →
LUAD	OS	Quartile	III,IV	0.372	0.865	.006	8	view →
GBM	DFS	Median	All	0.662	0.839	.005	4	view →
HNSC	DFS	Quartile	III,IV	0.906	0.716	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

C9–COAD (DFS)

Open the COAD breakdown →