C9

Across TCGA patient cohorts, C9 mutation is significantly associated with the RNA expression of many other genes, with 3,866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9-associated genes across cancer lineages are CDC45, SLC25A1, and MDC1. Each is linked with C9 in more than 4 cancer types. Because this analysis shows association rather than direction, both C9-to-partner and partner-to-C9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC45 grouped by C9-low versus C9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9→partner) and Y-score (partner→C9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDC45 →	+0.644	+2.375	<.001	<.001	3	5
UCEC	SLC25A1 →	+0.385	+1.950	.001	.002	3	4
UCEC	MDC1 →	+0.472	+2.042	<.001	.001	3	4
UCEC	CENPH →	+0.443	+1.389	.002	.005	3	4
UCEC	UBE2L3 →	+0.276	+2.078	.001	<.001	3	4
UCEC	C22orf39 →	+0.497	+1.828	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,866 associations by consensus.

CDC45 by C9 expression — UCEC

Explore this box plot interactively →