C9

Across TCGA cell cohorts, C9 RNA expression is significantly associated with the go_rna of many other GO terms, with 965 significant associations in total. BONE shows the largest number of these associations.

The most reproducible C9-associated GO terms across cancer lineages are Regulation of smooth muscle cell proliferation, Positive regulation of aldosterone biosynthetic process, and Response to carbohydrate. Each is linked with C9 in more than 5 cancer types. Because this analysis shows association rather than direction, both C9-to-partner and partner-to-C9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of smooth muscle cell proliferation grouped by C9-low versus C9-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C9→partner) and Y-score (partner→C9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of smooth muscle cell proliferation →	+0.078	+0.094	<.001	.001	3	6
SOFT_TISSUE	Positive regulation of aldosterone biosynthetic process →	+1.355	+0.068	<.001	<.001	3	5
LUNG_NSCLC_LUSC	Response to carbohydrate →	+0.102	+0.062	<.001	.006	3	5
PANCREAS	Regulation of epithelial to mesenchymal transition →	+0.063	+0.087	<.001	.006	2	5
OVARY	Quinone biosynthetic process →	-0.065	-0.038	.005	.006	3	4
OVARY	Regulation of aerobic respiration →	+0.065	+0.056	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 965 associations by consensus.

Regulation of smooth muscle cell proliferation by C9 expression — PANCREAS

Explore this box plot interactively →